The Immunoregulation of Th17 in Host against Intracellular Bacterial Infection

Table 1

The major characteristics of pathogenic intracellular bacterial species.

Serial number	Bacterial species	Gram staining	Facultative/obligatory	Diseases	Function of Th17/IL17
1	M. tuberculosis	Positive	Obligatory	Pulmonary infection, pleurisy, tuberculous pericarditis, bone tuberculosis, tubercular meningitis, tuberculous arthritis	(i) Recruit neutrophils, macrophages, Th1 cells and IFNγ-producing cells; (ii) Accelerate Th1 memory response
2	Listeria monocytogenes	Positive	Facultative	Septicemia, meningitis, monocytosis	(i) Promote adaptive CTL responses; (ii) Enhance DC cross-presentation; (iii) Accumulate innate neutrophils
3	(i) Chlamydia trachomatis; (ii) Chlamydia pneumoniae	Negative	Obligatory	Pelvic inflammatory disease, trachoma, pneumoniae	Promote DC functions
4	(i) Salmonella enterica serovar Enteritidis; (ii) Salmonella typhimurium	Negative	Facultative	Typhoid fever, paratyphoid fever, Enteritidis	IL23 is required for protection against the sublethal doses of S. Enteritidis
5	Francisella tularensis	Negative	Facultative	Tularemia	(i) Regulate the IL12-Th1 cell pathway; (ii) Induce IL12 and INF-γ production