PICK1 Deficiency Induces Autophagy Dysfunction via Lysosomal Impairment and Amplifies Sepsis-Induced Acute Lung Injury

Figure 4

Lysosome is impaired in PICK1^−/− mice. (a, b) Lungs were harvested 24 h post-CLP. Representative Western blot images and statistical analysis of LAMP1 and cathepsin B in PICK1^−/− mice. (c, d) Immunofluorescence and statistical analysis of LAMP1 in PICK1^−/− mice post-CLP (magnification, 200x). Results represent the mean ± SEM (/group). vs. sham-operated group in WT mice; vs. sham-operated group in PICK1^−/− mice.

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