PICK1 Deficiency Induces Autophagy Dysfunction via Lysosomal Impairment and Amplifies Sepsis-Induced Acute Lung Injury

Figure 6

Proposed model for PICK1 deficiency-related autophagy in sepsis-induced acute lung injury. In PICK1^−/− mice, impaired lysosomal structure decreases the function of lysosomes and influences the formation of autophagosomes with it. Accumulation of autophagosomes eventually result in autophagy dysfunction.