Applicability of Plant Extracts in Preclinical Studies of Melanoma: A Systematic Review

Figure 3

Article results. NF-κB (nuclear factor kappa B), AP-1 (activator protein 1), AKT (protein kinase B), PI3K (phosphatidylinositol-3-kinase), PCNA (proliferating cell nuclear antigen), MMP-2 and MMP-9 (metalloproteinases 2 and 9), PKCα (protein kinase C alpha), TIMP-1 and TIMP-2 (metallopeptidase inhibitors 1 and 2), NO (nitric oxide), GGT (gama-glutamil transpeptidase), KDR/FIK-1 (kinase insert domain receptor/fetal liver kinase 1), NK (natural killers), IL (interleukin), IFN-γ (interferon gama), TNF-α (tumor necrosis factor alfa), GM-CSF (granulocit-monocit colony stimulating factor), VEGF (vascular endothelial growth factor), FGF (fibroblast growth factor), EGF (epidermal growth factor), TGF-β (transforming growth factor-beta), HIF-1α (hypoxia-inducible factor-1α), COX-2 (cyclooxygenase 2), GSH (glutathione), and iNOS (inducible nitric oxide synthase).