Apoptosis-Associated Speck-Like Protein Containing a CARD Deletion Ameliorates Unilateral Ureteral Obstruction Induced Renal Fibrosis and Endoplasmic Reticulum Stress in Mice
Activation of ER stress induced by UUO is inhibited by ASC deficiency. (a) Immunoblotting for the levels of BIP, p-eIF2α/eIF2α, ATF4, and CHOP. (b) Quantification analysis of BIP, p-eIF2α/eIF2α, ATF4, and CHOP levels, normalized against those of β-actin. , WT/sham group versus WT/UUO group. , ASC−/−/UUO group versus WT/UUO group. Data represent the mean ± SEM ().