Selected Biomarkers Correlate with the Origin and Severity of Sepsis

Table 7

The comparison of biomarker levels between gram-positive and gram-negative sepsis.

Parameter	Day 1		Day 2		Day 3		Day 4
	G+	G−	G+	G−	G+	G−	G+	G−
MCP-1 (pg/mL)	576.40 (1188.61)	685.84 (4291.12)	505.33 (692.46)	786.23 (1593.18)	450.84 (742.37)	715.29 (848.93)	415.96 (438.42)	745.97 (616.07)	n.s.
MIP-1β (pg/mL)	43.49 (62.26)	48.99 (75.74)	43.03 (79.45)	39.39 (67.09)	39.11 (72.34)	28.45 (65.29)	37.78 (86.18)	36.79 (47.61)	n.s.
IL-6 (pg/mL)	47.74 (133.21)	18.96 (399.91)	20.98 (56.49)	27.98 (202.13)	11.28 (40.93)	11.21 (295.56)	2.65 (40.24)	15.02 (41.50)	n.s.
IL-8 (pg/mL)	80.54 (192.72)	106.62 (150.94)	60.14 (187.78)	31.43 (89.09)	65.83 (174.18)	40.56 (107.72)	63.23 (208.04)	34.49 (98.74)	n.s.
IL-10 (pg/mL)	6.32 (15.18)	1.90 (47.42)	1.90 (8.84)	3.64 (6.48)	1.90 (12.34)	1.90 (15.91)	1.90 (8.44)	1.90 (3.94)	n.s.
HBP (ng/mL)	236.33 (462.47)	288.59 (894.53)	122.42 (267.37)	162.18 (532.89)	111.85 (238.57)	124.47 (232.94)	82.94 (113.00)	115.96 (388.1)	n.s.
sCD14 (mg/L)	3.62 (1.34)	3.89 (1.12)	3.59 (1.48)	4.11 (1.14)	3.58 (1.39)	3.82 (1.24)	3.68 (2.24)	3.28 (1.64)	n.s.
Cortisol (nmol/L)	326.90 (290.20)	442.80 (400.25)	396.20 (421.4)	662.00 (2038.60)	423.20 (431.20)	545.55 (538.2)	452.60 (335.5)	416.15 (381.50)	0.048

Data are presented as median (quartile); n.s.: not significant; : gram-positive (G+) versus gram-negative (G−) infection. The statistical difference-analyzed parameters in the groups were analyzed by the Mann–Whitney U test.