Selected Biomarkers Correlate with the Origin and Severity of Sepsis
Table 8
The comparison of biomarker levels among the groups based on the source of sepsis.
Parameter
Day 1
Day 2
Day 3
Day 4
BM
IE
CAP
BM
IE
CAP
BM
IE
CAP
BM
IE
CAP
MCP-1 (pg/mL)
133.81,2 (149.0)
542.41 (693.2)
685.62 (1064.9)
130.01,2 (158.5)
624.51 (454.3)
667.72 (509.3)
154.11,2 (136.6)
489.51 (274.4)
581.52 (513.5)
221.11,2 (216.9)
471.81 (334.4)
605.32 (378.9)
MIP-1β (pg/mL)
25.0 (67.0)
40.6 (56.7)
23.1 (73.4)
14.2 (63.7)
29.7 (74.8)
12.8 (36.2)
16.4 (45.8)
30.1 (82.4)
13.8 (22.5)
23.3 (73.9)
26.9 (90.9)
13.4 (26.4)
IL-6 (pg/mL)
12.8 (46.5)
22.1 (113.8)
49.9 (191.9)
1.61,2 (10.4)
29.91 (76.3)
18.42 (91.2)
1.21,2 (6.9)
29.91 (61.0)
8.12 (96.0)
1.2 (12.1)
42.5 (92.1)
1.2 (25.9)
IL-8 (pg/mL)
13.1 (133.7)
37.3 (157.4)
47.1 (102.9)
14.2 (169.6)
34.7 (126.8)
22.6 (43.5)
32.3 (151.1)
33.6 (191.1)
34.4 (99.5)
44.7 (130.9)
52.4 (185.5)
25.1 (34.0)
IL-10 (pg/mL)
1.91,2 (0.0)
11.91 (17.7)
10.22 (6.6)
1.91 (0.0)
9.81 (14.4)
1.9 (7.6)
1.91 (0.0)
5.21 (14.5)
9.5 (13.3)
1.92 (0.0)
1.9 (7.2)
12.52 (14.2)
HBP (ng/mL)
110.11 (225.1)
369.61 (826.3)
96.7 (187.0)
92.1 (165.4)
189.5 (362.6)
57.2 (140.4)
66.8 (134.5)
230.2 (457.0)
102.5 (130.8)
43.4 (77.1)
111.3 (224.8)
155.2 (332.8)
sCD14 (mg/L)
3.02 (1.0)
4.0 (1.3)
4.52 (0.6)
2.81,2 (0.6)
4.21 (1.2)
4.02 (1.1)
2.61,2 (0.5)
3.91 (0.8)
3.72 (2.1)
2.31,2 (1.5)
4.01 (1.6)
4.22 (2.9)
Cortisol (nmol/L)
174.3 (146.9)
556.2 (531.9)
324.7 (555.8)
95.11 (75.7)
509.51 (450.8)
290.6 (377.4)
76.71,2 (88.7)
528.71 (217.8)
215.12 (329.3)
111.31 (248.5)
531.51,3 (143.3)
220.63 (305.6)
Data are presented as median (quartile); BM: bacterial meningitis; IE: infective endocarditis; CAP: community-acquired pneumonia; : BM versus IE; : BM versus CAP; : IE versus CAP. The statistical difference-analyzed parameters for multiple comparison were analyzed by the Kruskall-Wallis test.
