Long Noncoding RNAs and mRNA Regulation in Peripheral Blood Mononuclear Cells of Patients with Chronic Obstructive Pulmonary Disease

Table 7

Top 10 enriched GOs of targeted genes predicted to be regulated by dysregulated lncRNAs in COPD patients compared to smokers.

GO	value	Enrich score	Gene list
GO:0034612 response to tumor necrosis factor	0.000275	26.766	CCL3, THBS1, CXCL16, and CASP8
GO:0002685 regulation of leukocyte migration	0.00241	22.613	HMOX1, CCL3, and THBS1
GO:1,902,041 regulation of extrinsic apoptotic signaling pathway via death domain receptors	0.00252	41.244	THBS1 and HMOX1
GO:2,001,236 regulation of extrinsic apoptotic signaling pathway	0.00494	15.411	HMOX1, THBS1, and CASP8
GO:0002443 leukocyte-mediated immunity	0.00494	14.489	SLA2, IGHG1–001, and CCL3
GO:0002757 immune response-activating signal transduction	0.00494	9.249	SLA2, C5AR1, IGHG1–001, CASP8, and BIRC3
GO:0002687 positive regulation of leukocyte migration	0.00494	23.266	CCL3 and THBS1
GO:2,001,233 regulation of apoptotic signaling pathway	0.00494	8.922	HMOX1, SFPQ, THBS1, and CASP8
GO:0071356 cellular response to tumor necrosis factor	0.00494	20.39	CCL3 and THBS1
GO:0010035 response to inorganic substance	0.00494	8.309	HMOX1, PPP1R15B, THBS1, and CASP8