A Novel Association of Polymorphism in the ITGA4 Gene Encoding the VLA-4 α4 Subunit with Increased Risk of Alzheimer’s Disease
Table 3
Allele and genotypes frequencies of the ITGA4 −269A/C and +3061A/G polymorphism in APOE-ε4-positive AD patients and controls.
SNP/model
Allele/genotype
AD subjects ()
Controls ()
Univariate analysis
Multivariate analysis
OR (95% CI)
OR (95% CI)
−269 C/A
C
64 (82.05%)
68 (82.93%)
—
—
—
—
A
14 (17.95%)
14 (17.07%)
0.88
1.06 (0.47–2.40)
—
—
Codominant
CC
25 (64.10%)
27 (65.85%)
1.00
1.00
CA
14 (35.90%)
14 (34.15%)
0.87
1.08 (0.43–2.71)
0.95
0.97 (0.36–2.61)
AA
0 (00.00%)
0 (00.00%)
—
—
—
—
Dominant
CC
25 (64.10%)
27 (65.85%)
1.00
1.00
CA + AA
14 (35.90%)
14 (34.15%)
0.87
1.08 (0.43–2.71)
0.95
0.97 (0.36–2.61)
Recessive
CC + CA
39 (100.00%)
41 (100.00%)
—
—
—
—
AA
0 (00.00%)
0 (00.00%)
—
—
—
—
+3061 A/G
A
53 (67.95%)
57 (69.51%)
—
—
—
—
G
25 (32.05%)
25 (30.49%)
0.83
1.08 (0.55–2.10)
—
—
Codominant
AA
17 (43.59%)
18 (43.90%)
1.00
1.00
AG
19 (48.72%)
21 (51.22%)
0.87
0.96 (0.39–2.38)
0.87
0.93 (0.35–2.47)
GG
3 (7.69%)
2 (4.88%)
—
1.59 (0.24–10.70)
—
1.58 (0.22–11.39)
Dominant
AA
17 (43.59%)
18 (43.90%)
1.00
1.00
AG + GG
22 (56.41%)
23 (56.10%)
0.98
1.01 (0.42–2.45)
0.99
0.99 (0.39–2.56)
Recessive
AA + AG
36 (92.31%)
39 (95.12%)
1.00
1.00
GG
3 (7.69%)
2 (4.88%)
0.6
1.62 (0.26–10.29)
0.61
1.64 (0.24–11.11)
Overdominant
AA + GG
20 (51.28%)
20 (48.78%)
1.00
1.00
AG
19 (48.72%)
21 (51.22%)
0.82
0.90 (0.38–2.17)
0.79
0.88 (0.34–2.26)
Haplotypes
CA
60.48%
62.69%
1.00
1.00
CG
21.57%
20.23%
0.81
1.11 (0.46–2.68)
0.78
1.15 (0.45–2.93)
AG
10.48%
10.26%
0.88
1.10 (0.32–3.77)
0.96
0.97 (0.25–3.70)
AA
7.47%
6.82%
0.86
1.15 (0.24–5.50)
0.93
1.09 (0.19–6.11)
Allele and genotype frequencies are presented as absolute numbers with percentages in parentheses. OR: odds ratio; CI: confidence interval. Univariate analysis is based on the χ2 test. Multivariate analysis is adjusted by gender and age. is considered as significant.
