A Novel Association of Polymorphism in the ITGA4 Gene Encoding the VLA-4 α4 Subunit with Increased Risk of Alzheimer’s Disease
Table 4
Allele and genotype frequencies of the ITGA4 −269A/C and +3061A/G polymorphism in APOE-ε4-negative AD patients and controls.
SNP/model
Allele/genotype
AD subjects ()
Controls ()
Univariate analysis
Multivariate analysis
OR (95% CI)
OR (95% CI)
−269 C/A
C
106 (81.54%)
271 (82.12%)
—
—
—
—
A
24 (18.46%)
59 (17.88%)
0.88
1.04 (0.62–0.76)
—
—
Codominant
CC
41 (63.08%)
106 (64.24%)
1.00
1.00
CA
24 (36.92%)
59 (35.76%)
0.87
1.05 (0.58–1.91)
1.00
1.00 (0.54–1.85)
AA
0 (00.00%)
0 (00.00%)
—
—
—
—
Dominant
CC
41 (63.08%)
106 (64.24%)
1.00
1.00
CA + AA
24 (36.92%)
59 (35.76%)
0.87
1.05 (0.58–1.91)
1.00
1.00 (0.54–1.85)
Recessive
CC + CA
65 (100.00%)
165 (100.00%)
—
—
—
—
AA
0 (00.00%)
0 (00.00%)
—
—
—
—
+3061 A/G
A
82 (63.08%)
237 (71.82%)
—
—
—
—
G
48 (36.92%)
93 (28.18%)
0.07
1.49 (0.97–2.29)
—
—
Codominant
AA
22 (33.85%)
88 (53.33%)
1.00
1.00
AG
38 (58.46%)
61 (36.97%)
0.012
2.49 (1.34–4.62)
0.025
2.37 (1.26–4.48)
GG
5 (7.69%)
16 (9.70%)
—
1.25 (0.41–3.78)
—
1.34 (0.43–4.20)
Dominant
AA
22 (33.85%)
88 (53.33%)
1.00
1.00
AG + GG
43 (66.15%)
77 (46.67%)
0.007
2.23 (1.23–4.06)
0.012
2.18 (1.18–4.03)
Recessive
AA + AG
60 (92.31%)
149 (90.30%)
1.00
1.00
GG
5 (7.69%)
16 (9.70%)
0.63
0.78 (0.27–2.21)
0.77
0.85 (0.29–2.50)
Overdominant
AA + GG
27 (41.54%)
104 (63.03%)
1.00
1.00
AG
38 (58.46%)
61 (36.97%)
0.003
2.40 (1.34–4.31)
0.008
2.26 (1.24–4.12)
Haplotypes
CA
56.88%
63.97%
1.00
1.00
CG
24.66%
18.15%
0.14
1.55 (0.87–2.75)
0.17
1.51 (0.84–2.72)
AG
12.26%
10.03%
0.42
1.37 (0.63–2.96)
0.40
1.40 (0.64–3.06)
AA
6.20%
7.85%
0.87
0.91 (0.30–2.77)
0.67
0.78 (0.25–2.45)
Allele and genotype frequencies are presented as absolute numbers with percentages in parentheses. OR: odds ratio; CI: confidence interval. Univariate analysis is based on the χ2 test. Multivariate analysis is adjusted by gender and age. is considered as significant.
