Mast Cells Exert Anti-Inflammatory Effects in an IL10<sup>−/−</sup> Model of Spontaneous Colitis

<div>Spontaneous colonic cytokine production. (a) TNF is increased in DKO mice compared to IL10<sup>−/−</sup> and is restored to baseline in DKO mice that are reconstituted with BMMCs. (b) IL12p40 is increased in DKO mice compared to IL10<sup>−/−</sup> but is unaffected by BMMC reconstitution. (c) Colonic IL6 is similar between IL10<sup>−/−</sup>, DKO, and DKO mice reconstituted with BMMCs. (d) TNF is also restored to baseline in DKO mice reconstituted with IL10<sup>−/−</sup> BMMCs compared to DKO mice. 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Mediators of Inflammation

fig4

Figure 4

Figure 4: Mast Cells Exert Anti-Inflammatory Effects in an IL10<sup>−/−</sup> Model of Spontaneous Colitis 

Mediators of Inflammation

Mast Cells Exert Anti-Inflammatory Effects in an IL10−/− Model of Spontaneous Colitis

Figure 4

Mast Cells Exert Anti-Inflammatory Effects in an IL10^−/− Model of Spontaneous Colitis