Macrophage LRP1 Promotes Diet-Induced Hepatic Inflammation and Metabolic Dysfunction by Modulating Wnt Signaling

Figure 1

Reduced body weight gain and improved glucose tolerance for LDLR^−/−; macLRP1^−/− mice. LDLR^−/− and LDLR^−/−; macLRP1^−/− mice were maintained on a Western diet for 8 weeks prior to conducting the intraperitoneal glucose tolerance test (IPGTT). (a) Percent body weight gain of mice after 8 weeks (LDLR^−/−, LDLR^−/−; macLRP1^−/−). IPGTT (1 mg/g glucose challenge) curve depicting glucose clearance capacity (b) and area under the curve (AUC, c) of LDLR^−/− () and LDLR^−/−; macLRP1^−/− () mice. (d) Plasma insulin levels during the IPGTT (LDLR^−/− and LDLR^−/−; macLRP1^−/−). The data represent mean ± SEM of results. .

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