Macrophage LRP1 Promotes Diet-Induced Hepatic Inflammation and Metabolic Dysfunction by Modulating Wnt Signaling

Figure 2

LRP1 expression increased diet-induced liver inflammation in mice. (a) LDLR^−/− and LDLR^−/−; macLRP1^−/− mice were maintained on a Western diet for 2 weeks. Livers were processed and analyzed for abundance of inflammatory cytokines Ccl3, Ccl4, Ccl8, Ccr1, Ccr2, Cxcl9, and Tnf by quantitative RT-PCR (). (b) Insulin receptor and Glut2 (Insr and Slc2a2, respectively) expression levels were analyzed for abundance by quantitative RT-PCR (). The data represent mean ± SEM of results. , .

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