Serotonin Exhibits Accelerated Bleomycin-Induced Pulmonary Fibrosis through TPH1 Knockout Mouse Experiments

Figure 1

Effect of 5-HT on weight loss induced by bleomycin in mice. Intratracheal instillation of bleomycin (BLM) hydrochloride was performed to induce pulmonary fibrosis in wild-type C57BL/6 (WT) and TPH1 knockout (KO) mice. The changes in body weight of mice from the WT and KO control, WT BLM, and KO BLM groups were examined over the 21-day study period. All data were expressed as , . and versus the WT BLM group.