Fecal Galectin-3: A New Promising Biomarker for Severity and Progression of Colorectal Carcinoma

Figure 1

(a) Increased concentration of Gal-3 in feces and Gal-3/TNF-α ratio in sera, in patients with a higher nuclear grade of CRC. Patients with CRC were divided into three groups, based on nuclear grades (I, II, and III). Serum and fecal levels of all mentioned biomarkers were determined by ELISA. Gal-3/TNF-α ratios were evaluated for each patient, separately. Kruskal–Wallis test was used to determinate statistically significant difference between the means of three groups. (b) Increased concentrations of IL-10, TGF-β, and Gal-3 in the feces of patients with poor histological differentiation of CRC. Patients with CRC were divided into two groups, according to histological differentiation rate (well/moderate and poor). Statistical significance was tested by Mann–Whitney Rank Sum test.

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