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lncRNAs | Description of evidence | References |
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lincRNA-Cox2 | lincRNA-Cox2 regulates the expression of inflammatory genes by binding with hnRNP-A/B and A2/B1. It also can interact with SWI/SNF complex in macrophages, to create lincRNA-Cox2/SWI/SNF complex, subsequently mediating SWI/SNF-associated chromatin remodeling and transcriptional activation of the late-primary inflammatory response genes. lincRNA-Cox2 represses the transcription of IL-12b in response to TNF-α stimulation. | [21–24] |
PACER | PACER interacts with the repressive NF-κB subunit p50, enables it divorced from the COX-2 promoter, and favors the recruitment of the p300 histone acetyltransferase and RNA polymerase II (RNAPII) preinitiation complexes in the promoter region of Cox2 to promote COX-2 transcription. | [25] |
Lethe | Lethe binds to the active NF-κB subunit p65 (RelA) and prevents it from binding to the promoters of target genes, thus reducing the production of inflammatory proteins, such as IL-6, IL-8, and superoxide dismutase 2 (SOD2). | [26] |
THRIL | THRIL interacts with hnRNPL to establish a functional THRIL-hnRNPL complex, consequently regulating TNF-α transcription by binding to its promoter. | [28] |
NEAT1 | NEAT1 binds to SFPQ, relocating it from the IL-8 promoter to the paraspeckles and resulting in the activation of IL-8 transcription; knockdown of NEAT1 can enhance virus production by increasing nucleus-to-cytoplasm export of HIV-1 mRNA. | [29–31] |
AS-IL1α | AS-IL1α favors the recruitment of RNAPII to the IL-1α promoter, thus controlling the transcriptional activation of IL-1α. | [32] |
Lnc-IL7R | Lnc-IL7R regulates trimethylation of histone H3 at lysine 27 (H3K27me3) and increases its level at the promoters of E-selectin and VCAM-1, suppressing the expression of the two genes. | [33] |
Lnc-DC | Lnc-DC promotes phosphorylation and activation of STAT3, a transcription essential for DC differentiation, by blocking its dephosphorylation by SHP1. | [35] |
HOTAIRM1 | HOTAIRM1 regulates RA-induced expression of HOXA1 and HOXA4 during the RA-induced granulocyte differentiation of NB4 cells and promotes induction of CD11b and CD18 expression, two hallmarks for granulocyte differentiation. | [40] |
IL-1β-eRNA and IL1β-RBT46 | IL-1β-eRNA or IL1β-RBT46 regulates LPS-induced production of the proinflammatory factors, such as IL-1β and CXCL8. | [41] |
FIRRE | FIRRE can positively regulate the expression of several inflammatory genes at the posttranscriptional level through its interaction with hnRNPU. | [44] |
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