Research Article
Involvement of the IL23/Th17 Pathway in the Pathogenesis of Tunisian Pemphigus Foliaceus
Table 3
Genotype and allele frequencies of IL23/Th17 pathway’s genes polymorphisms in Pemphigus foliaceus patients and matched healthy controls.
| | Gene/SNP | Genotype/allele | Case N (%) | Control N (%) | | OR | 95% CI |
| IL23R
rs11209026 | AA | 0 | 5 (2.6) | NS | — | — | | AG | 11 (10.3) | 41 (21.2) | 0.016 | 0.42 | 0.21–0.87 | | GG | 96 (89.7) | 147 (76.2) | 0.004 | 2.37 | 1.35–5.53 | | A | 11 (5.1) | 51 (13.2) | 0.001 | 0.35 | 0.18–0.69 | | G | 203 (94.9) | 335 (86.8) | | | |
| IL23R
rs1884444 | GG | 3 (3) | 11 (8.3) | NS | — | — | | GT | 80 (79.2) | 106 (79.7) | NS | — | — | | TT | 18 (17.8) | 16 (12) | NS | — | — | | G | 86 (42.6) | 128 (48.1) | NS | — | — | | T | 116 (57.4) | 138 (51.9) | | | |
| IL23R
rs7517847 | GG | 10 (9.8) | 14 (7.4) | NS | — | — | | GT | 43 (42.2) | 75 (39.7) | NS | — | — | | TT | 49 (48) | 100 (52.9) | NS | — | — | | G | 63 (30.9) | 103 (27.2) | NS | — | — | | T | 141 (69.1) | 276 (72.8) | | | |
| IL23R
rs10889677 | AA | 20 (19.8) | 40 (22.1) | NS | — | — | | AC | 41 (40.6) | 71 (39.2) | NS | — | — | | CC | 40 (39.6) | 70 (38.7) | NS | — | — | | A | 81 (40.1) | 151 (41.7) | NS | — | — | | C | 121 (59.9) | 211 (58.3) | | | |
| IL17A
rs2275913 | AA | 1 (1) | 1 (0.6) | NS | — | — | | AG | 9 (9.2) | 10 (6.2) | NS | — | — | | GG | 88 (89.8) | 150 (93.2) | NS | — | — | | A | 11 (5.6) | 12 (3.7) | NS | — | — | | G | 185 (94.4) | 310 (96.3) | | | |
| IL17A
rs3748067 | TT | 0 | 4 (3.6) | NS | — | — | | CT | 10 (11.1) | 38 (35) | 9.47e − 4 | 0.23 | 0.11–0.50 | | CC | 79 (87.7) | 66 (60.8) | 1.17e − 4 | 5.03 | 2.34–10.78 | | T | 10 (5.5) | 46 (21.1) | 8.29e − 6 | 0.218 | 0.10–0.44 | | C | 170 (94.4) | 171 (78.8) | | | |
| IL17AR
rs4819554 | AA | 78 (74.3) | 137 (71.8) | NS | — | — | | AG | 24 (22.9) | 48 (25.1) | NS | — | — | | GG | 3 (2.9) | 6 (3.1) | NS | — | — | | A | 180 (85.7) | 322 (84.3) | NS | — | — | | G | 30 (14.3) | 60 (15.7) | | | |
| IL17F
rs763780 | CC | 5 (4.7) | 3 (1.6) | NS | — | — | | CT | 13 (12.3) | 13 (6.7) | NS | — | — | | TT | 88 (83) | 177 (91.7) | 0.02 | 0.44 | 0.22–0.91 | | C | 23 (10.8) | 19 (4.9) | 0.007 | 2.35 | 1.24–4.42 | | T | 189 (89.2) | 367 (95.1) | | | |
| TNFa
rs1800629 | AA | 12 (12.8) | 9 (5) | 0.022 | 2.76 | 1.12–6.82 | | AG | 37 (39.4) | 43 (24) | 0.008 | 2.05 | 1.20–3.51 | | GG | 45 (47.9) | 127 (70.9) | 0.0002 | 0.38 | 0.22–0.63 | | A | 61 (32.4) | 61 (17) | 4.06e − 5 | 2.33 | 1.55–3.52 | | G | 127 (67.6) | 297 (83) | | | |
| RORγt
rs9645406 | TT | 0 | 0 | NS | — | — | | CT | 9 (7.9) | 13 (6.5) | NS | — | — | | CC | 106 (92.1) | 188 (93.5) | NS | — | — | | T | 11 (4.7) | 13 (3.3) | NS | — | — | | C | 219 (95.3) | 389 (96.7) | NS | — | — |
| STAT3
rs744166 | TT | 22 (23.1) | 29 (18.1) | NS | — | — | | CT | 47 (49.5) | 77 (48.1) | NS | — | — | | CC | 26 (27.4) | 54 (33.8) | NS | — | — | | T | 91 (47.9) | 135 (42.2) | NS | — | — | | C | 99 (52.1) | 185 (57.8) | NS | — | — |
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