Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors

Figure 3

mTORC1 is activated in both M1 and M2 polarization and regulates important metabolic processes at both conditions. AA: amino acids; ACLY: ATP citrate lyase; HIF-1α: hypoxic inducible factor 1α; IL-4: interleukin 4; IL-13: interleukin 13; PGC1α: PPARγ coactivator 1α; PPARγ: peroxisome proliferator-activated receptor γ; TLR4: toll like receptor 4.