Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors

Figure 4

mTORC2 is activated in both M1 and M2 polarization and regulates important metabolic processes at both conditions. IL-1β: interleukin 1β; IL-4: interleukin 4; IL-13: interleukin 13; IRF4: interferon regulatory factor 4; LPS: lipopolysaccharide; PKB: protein kinase B; PPARγ: peroxisome proliferator-activated receptor γ; TLR4: toll-like receptor 4; TNF-α: tumor necrosis factor-α.