Lactate as a Potential Biomarker of Sepsis in a Rat Cecal Ligation and Puncture Model
Table 1
Comparison of parameters between the S group and NS group (mean ± SD).
Parameter
Time
NS group
S group
Body weight (g)
Baseline
484.6 ± 19.2
480.5 ± 15.0
CLP 24 h
469.6 ± 16.1
464.8 ± 13.5
PCT (pg/ml)
Baseline
66.2 ± 11.1
62.2 ± 9.8
CLP 24 h
82.8 ± 12.5
208.3 ± 44.5#
HMGB1 (ng/ml)
Baseline
0.6 ± 0.2
0.5 ± 0.2
CLP 24 h
0.9 ± 0.3
5.5 ± 1.4#
BUN (mmol/L)
Baseline
4.9 ± 1.4
4.5 ± 1.4
CLP 24 h
5.3 ± 0.9
15.8 ± 3.6#
ALT (UI/L)
Baseline
24.5 ± 7.7
27.6 ± 8.0
CLP 24 h
28.3 ± 7.7
64.2 ± 11.1#
cTnI (ng/ml)
Baseline
0.4 ± 0.2
0.4 ± 0.1
CLP 24 h
0.5 ± 0.2
2.1 ± 0.9#
PaO2/FiO2
Baseline
477.5 ± 33.0
473.9 ± 37.1
CLP 24 h
471.9 ± 29.7
347.8 ± 40.5#
MAP (mmHg)
Baseline
119.8 ± 7.0
121.6 ± 7.9
CLP 24 h
115.7 ± 12.5
84.4 ± 19.6#
Lac (mmol/L)
Baseline
0.7 ± 0.2
0.8 ± 0.3
CLP 24 h
1.3 ± 0.4
2.2 ± 0.6#
Bacterial counts (Log cfu/ml)
Baseline
0
0
CLP 24 h
3.78 ± 0.20
3.87 ± 0.23
CLP: cecal ligation and puncture; PCT: procalcitonin; HMGB1: high-mobility group box 1; BUN: blood urea nitrogen; ALT: alanine aminotransferase; cTnI: cardiac troponin i; PaO2/FiO2: oxygenation index; MAP: mean arterial pressure; Lac: blood lactate; cfu: colony-forming units. S group: animals that met the septic thresholds after CLP insult (); NS group: animals that did not meet the septic thresholds after CLP insult (). versus baseline, # versus NS group.
