Mediators of Inflammation / 2018 / Article / Tab 1

Research Article

Lactate as a Potential Biomarker of Sepsis in a Rat Cecal Ligation and Puncture Model

Table 1

Comparison of parameters between the S group and NS group (mean ± SD).

ParameterTimeNS groupS group

Body weight (g)Baseline484.6 ± 19.2480.5 ± 15.0
CLP 24 h469.6 ± 16.1464.8 ± 13.5

PCT (pg/ml)Baseline66.2 ± 11.162.2 ± 9.8
CLP 24 h82.8 ± 12.5208.3 ± 44.5#

HMGB1 (ng/ml)Baseline0.6 ± 0.20.5 ± 0.2
CLP 24 h0.9 ± 0.35.5 ± 1.4#

BUN (mmol/L)Baseline4.9 ± 1.44.5 ± 1.4
CLP 24 h5.3 ± 0.915.8 ± 3.6#

ALT (UI/L)Baseline24.5 ± 7.727.6 ± 8.0
CLP 24 h28.3 ± 7.764.2 ± 11.1#

cTnI (ng/ml)Baseline0.4 ± 0.20.4 ± 0.1
CLP 24 h0.5 ± 0.22.1 ± 0.9#

PaO2/FiO2Baseline477.5 ± 33.0473.9 ± 37.1
CLP 24 h471.9 ± 29.7347.8 ± 40.5#

MAP (mmHg)Baseline119.8 ± 7.0121.6 ± 7.9
CLP 24 h115.7 ± 12.584.4 ± 19.6#

Lac (mmol/L)Baseline0.7 ± 0.20.8 ± 0.3
CLP 24 h1.3 ± 0.42.2 ± 0.6#

Bacterial counts (Log cfu/ml)Baseline00
CLP 24 h3.78 ± 0.203.87 ± 0.23

CLP: cecal ligation and puncture; PCT: procalcitonin; HMGB1: high-mobility group box 1; BUN: blood urea nitrogen; ALT: alanine aminotransferase; cTnI: cardiac troponin i; PaO2/FiO2: oxygenation index; MAP: mean arterial pressure; Lac: blood lactate; cfu: colony-forming units. S group: animals that met the septic thresholds after CLP insult (); NS group: animals that did not meet the septic thresholds after CLP insult (). versus baseline, # versus NS group.