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Mediators of Inflammation
Volume 2018 (2018), Article ID 8430614, 10 pages
Research Article

Dietary n-3 PUFA May Attenuate Experimental Colitis

1INSERM UMR 1073, UFR de Médecine-Pharmacie, 22 boulevard Gambetta, 76183 Rouen Cedex, France
2Department of Gastroenterology, Rouen University Hospital, 1 rue de Germont, 76031 Rouen Cedex, France
3University of Calgary, Gastrointestinal Research Group, Snyder Institute for Chronic Diseases, Calgary, AB, Canada
4Center for Advanced IBD Research and Treatment, Kitasato Institute Hospital, Tokyo, Japan
5Nutrition Unit, Rouen University Hospital, 1 rue de Germont, 76031 Rouen Cedex, France
6Institute of Translational Medicine, University of Birmingham, Birmingham, UK

Correspondence should be addressed to Subrata Ghosh

Received 28 July 2017; Revised 13 October 2017; Accepted 31 October 2017; Published 15 February 2018

Academic Editor: Sung-Ling Yeh

Copyright © 2018 Cloé Charpentier et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Inflammatory bowel diseases (IBD) occurred in genetically predisposed people exposed to environmental triggers. Diet has long been suspected to contribute to the development of IBD. Supplementation with n-3 polyunsaturated fatty acids (PUFA) protects against intestinal inflammation in rodent models while clinical trials showed no benefits. We hypothesized that intervention timing is crucial and dietary fatty acid pattern may influence intestinal environment to modify inflammation genesis. The aim of this study was to evaluate the dietary effect of PUFA composition on intestinal inflammation. Methods. Animals received diet varying in their PUFA composition for four weeks before TNBS-induced colitis. Colon inflammatory markers and gut barrier function parameters were assessed. Inflammatory pathway PCR arrays were determined. Results. n-3 diet significantly decreased colon iNOS, COX-2 expression, IL-6 production, and LTB4 production but tended to decrease colon TNFα production () compared to control diet. Tight junction protein (claudin-1, occludin) expressions and MUC2 and TFF3 mRNA levels were not different among groups. n-9 diet also decreased colon IL-6 production (). Conclusions. Dietary n-3 PUFA influence colitis development by attenuating inflammatory markers. Further research is required to better define dietary advice with a scientific rationale.