Dietary n-3 PUFA May Attenuate Experimental Colitis

Table 2

Inflammation pathway PCR array in rats receiving diets varying in their unsaturated fatty acid composition followed by TNBS-induced colitis. Colon RNA from rats receiving diets varying in their unsaturated fatty acid composition before the onset of TNBS-induced colitis. The results were compared to rats receiving TNBS with a control diet. Data in bold are significantly different from TNBS rats.

	n-3 diet		n-6 diet		n-9 diet
	Fold regulation	value	Fold regulation	value	Fold regulation	value
Il1a	2.29	0.044	1.33	0.224	1.50	0.157
Il1b	1.60	0.125	1.09	0.776	−1.03	0.879
Il12a	−1.64	0.113	−1.12	0.532	−1.41	0.226
Il6	1.54	0.363	−2.76	0.219	−1.10	0.656
TNF	1.40	0.138	1.32	0.260	1.24	0.393
Ifng	1.06	0.417	2.30	0.124	1.78	0.183
Il10	1.49	0.378	−1.36	0.793	1.16	0.776
Il1r1	1.39	0.205	1.26	0.446	1.11	0.864
Hmgb1	1.09	0.492	1.52	0.042	1.02	0.851
Map2k3	1.65	0.021	1.36	0.117	1.2	0.278
Il2	−1.27	0.904	4.23	0.258	3.13	0.275
Clec4e	1.46	0.372	−2.13	0.184	−1.37	0.724
Lta	−1.04	0.572	−2.44	0.351	−1.09	0.952
Cd86	−1.11	0.569	−1.12	0.778	−1.52	0.163
Fos	−1.05	0.345	−1.3	0.379	−1.32	0.214
Irf1	−1.32	0.451	1.08	0.988	1.02	0.693
Jun	−1.37	0.340	1.09	0.762	−1.34	0.158
Tlr1	1.23	0.419	−1.05	0.803	1.06	0.654
Tlr2	1.73	0.013	1.18	0.320	1.16	0.371
Tlr3	−1.38	0.320	1.25	0.659	1.11	0.846
Tlr4	1.49	0.140	1.34	0.251	2.01	0.005
Tlr5	−1.09	0.805	1.18	0.815	1.49	0.758
Tlr6	1.26	0.381	1.02	0.855	1.05	0.960
Tlr7	−1.37	0.397	−1.44	0.207	−1.29	0.299
Tlr9	−1.24	0.802	−1.18	0.877	−1.47	0.285