Restoring Inflammatory Mediator Balance after Sofosbuvir-Induced Viral Clearance in Patients with Chronic Hepatitis C
Table 3
Expression pattern of cytokines in chronic hepatitis C patients with different liver disease status.
F0–F3
F4 child A
F4 child B or C
value
Chemokines
CCL-3
3.1 (1.8–8.5)
12.1 (0.8–28.8)
2.1 (1.3–11.8)
NS
CCL-4
46.1 (31.8–56.9)
74.9 (38.0–111.7)
49.4 (33.4–79.7)
NS
CCL-5
2526 (1962–3828)
3978 (1970–5719)
3089 (1874–4779)
NS
CCL-11
722.7 (620.7–869.1)
466.5 (347.4–845.2)
1004 (717.5–1625)
0.003
CXCL-8
36.6 (24.8–60.3)
66.7 (40.5–90.6)
62.7 (26.7–234.7)
NS
CXCL-10
29,024 (17571–38,389)
29,385 (14,847–33,201)
27,127 (14,624–52,988)
NS
Proinflammatory
IFN-γ
98.4 (48.6–194.3)
74.9 (53.4–1417.0)
92.5 (46.8–450.6)
NS
IL-1β
0.1 (0.1–0.8)
0.7 (0.3-4.1)
0.3 (0.1-2.7)
NS
IL-15
2.2 (1.0–10.0)
2.9 (0.5–7.6)
4.8 (1.3–27.5)
NS
Anti-inflammatory
IL-10
5.3 (3.3–6.0)
2.9 (2.1–3.8)
4.5 (2.7–11.6)
NS
IL-1ra
215.5 (73.8–468.2)
293.3 (151.9–1894.0)
207.9 (55.4–1660.0)
NS
TGF-β
3146 (2707–3935)
2300 (1856–2879)
2468 (1629–3286)
NS
Growth factors
FGFb
478.2 (125.5–1595.0)
447.4 (302.4–885.1)
143.1 (139.9–187.7)
0.019
PDGF-BB
29,579 (2670–133,040)
7932 (2250–23,508)
3198 (133.1–62,475)
NS
VEGF
62.9 (32.8–119.3)
80.3 (41.0–271.8)
58.0 (43.2–191.5)
NS
Others
PAI-1
20,154 (15,668–23,239)
9927 (5816–13,729)
19,469 (15,882–25,636)
0.0007
suPAR
1759 (1587–2108)
2441 (2006–2992)
3365 (2888–4062)
0.0006
Data are presented as median (interquartile range). NS: nonsignificant. The analysis of CCL-2 was not performed due to insufficient number of patients. Statistical significance was assessed by ANOVA with Bonferroni’s posttest or Kruskal-Wallis test with Dunn’s posttest (). The bold numbers indicate values < 0.05.
