CD38 Deficiency Promotes Inflammatory Response through Activating Sirt1/NF-κB-Mediated Inhibition of TLR2 Expression in Macrophages

Figure 1

CD38 deficiency attenuates the expressions of TLR2 mRNA and protein in macrophages. The expressions of TLR2 mRNA (a) and protein (b) were quantitatively analyzed with primary macrophages from WT and CD38^−/− mice, and GAPDH was used as an internal control. The expressions of CD38 and TLR2 mRNA (c) and protein (d) were determined by qRT-PCR and Western blot, respectively, in RAW264.7 cells after a 72 h transfection with various CD38 sgRNAs. The data represent the . from three independent experiments, compared with the WT group.

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