CD38 Deficiency Promotes Inflammatory Response through Activating Sirt1/NF-κB-Mediated Inhibition of TLR2 Expression in Macrophages

Figure 2

Identification of the transcription factors of the TLR2 gene in RAW264.7 cells. A series of truncated TLR2 promoter luciferase constructs were prepared, and the numbers represent the distance from the transcription start site to the truncated positions (a). The luciferase activities of the constructs of the various truncated TLR2 promoters were determined and normalized to the Renilla luciferase activity (b). The potential transcription factor-binding motifs of TLR2 were determined by using the Motifmap software programs (c). The data represent the . from three independent experiments.

(a)

(b)

(c)