Mediators of Inflammation / 2018 / Article / Fig 3

Review Article

Role of Epidermal Growth Factor Receptor (EGFR) and Its Ligands in Kidney Inflammation and Damage

Figure 3

Different signaling pathways related to EGFR activation induced by CTGF/EGFR interaction. CTGF binds to EGFR through its C-terminal module. This interaction activates the EGFR signaling pathway linked to the modulation of different pathways closely related with cell growth, oxidative process, inflammation, EMT, and fibrosis in renal damage.

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