Dynamic DNA Methylation Changes of Tbx21 and Rorc during Experimental Autoimmune Uveitis in Mice

Figure 1

The methylation level of Tbx21 and Rorc in the retinas and RPE-choroid complexes of EAU mice at different time points. The retinal methylation changes of CpG_1 for Tbx21 (a) and Rorc (b) at different time points during EAU were detected with a MALDI-TOF mass spectrometer (, , , and ). In the RPE-choroid complexes, the methylation levels of Tbx21 in CpG_1 (c) and CpG_5 (d) and Rorc in CpG_5 (e) also showed a dynamic alteration with statistical difference (, , , and ). The data are shown as mean ± SEM. One-way ANOVA followed by Bonferroni correction was used to compare the methylation levels in multiple groups.