Dynamic DNA Methylation Changes of Tbx21 and Rorc during Experimental Autoimmune Uveitis in Mice

Figure 4

Correlation between the methylation levels of significantly changed CpG sites and the mRNA expression of Tbx21 and Rorc in the RPE-choroid complexes of EAU mice at different time points. The methylation level of CpG-1 and CpG-5 in Tbx21 (a, b) and CpG-5 in Rorc (c) were negatively correlated with their mRNA expression in the RPE-choroid complexes of the mice. Pearson correlation test was used to perform the correlation analysis between the significantly changed methylation CpG sites and the mRNA expression levels of Tbx21and Rorc.