CD3+ B-1a Cells as a Mediator of Disease Progression in Autoimmune-Prone Mice

Figure 1

Cumulative prevalence of proteinuria and lymphoid hyperplasia. Urine protein and lymphadenopathy were monitored every week, starting at 6 weeks of age. Urine protein measured using tetrabromophenol paper over time in the B6/lpr (a) and MRL/lpr (b) mice. Cervical, axillary, and inguinal lymph node hyperplasias, 5 mm or larger, were monitored visually in the B6/lpr (c) and MRL/lpr (d) mice.

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