Gut Microbiota as a Driver of Inflammation in Nonalcoholic Fatty Liver Disease

Table 1

Gut microbiota alteration in human studies (NASH = nonalcoholic steatohepatitis; SS = simple steatosis; HC = healthy controls).

Study	Subjects	Gut microbiota alterations
Mouzaki et al. [35]	NAFLD (SS or NASH) and HC	↑ Clostridium coccoides in NASH versus SS; ↓ Bacteroidetes in NASH versus SS and HC
Boursier et al. [36]	NAFLD (SS, NASH, and fibrosis)	↑ Bacteroides and ↓ Prevotella in NASH; ↑ Bacteroidaceae; ↓ Prevotellaceae and Erysipelotrichaceae according to the severity of NASH; ↑ Bacteroides and Ruminococcus and ↓ Prevotella in patients with F2 fibrosis versus F0/F1
Raman et al. [37]	NAFLD and HC	↑ Lactobacillus and selected members of Firmicutes (Dorea, Robinsoniella, and Roseburia); ↓ one member of Firmicutes (Oscillibacter) in NAFLD
Wong et al. [38]	NASH and HC	↑ Parabacteroides and Allisonella; ↓ Firmicutes and Faecalibacterium in NASH
Mouzaki et al. [39]	NAFLD (SS and NASH) and HC	↓ Bacteroidetes and Clostridium leptum in NASH versus HC
Zhu et al. [31]	Children—NASH, obese, and HC	↑ Bacteriodetes and Proteobacteria and ↓ Firmicutes and Actinobacteria in NASH versus HC
Del Chierico et al. [41]	Children—NAFLD (SS and NASH), obese, and HC	↑ Bradyrhizobium, Anaerococcus, Peptoniphilus, Propionibacterium acnes, Dorea, and Ruminococcus and ↓ Oscillospira and Rikenellaceae in NAFLD