Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence

Figure 4

A patient presents with aGVHD after early GVHD prophylaxis withdrawal. Palmar (top) and plantar (bottom right) erythema and bullae formations are typical skin manifestations of aGVHD. The erythema of the face spreads to the neck, chest, and shoulders often resulting into generalized erythroderma. aGVHD manifestation in the oral cavity involves stomatitis and cheilitis (bottom left). The face shows signs of cushingoid features resulting from adverse side effects of corticosteroids.