Insulin-Like Growth Factor-I as an Effector Element of the Cytokine IL-4 in the Development of a Leishmania major Infection

Figure 1

The effects of IGF-I on the growth of L. major in culture and within macrophages ( deviation). (a) The effect of IGF-I on the growth of Leishmania promastigotes in culture maintained in 199 medium supplemented with 2% heat-inactivated FCS at 26°C is shown. Leishmania promastigotes were maintained with (gray line) or without (black line) 50 ng/mL rIGF-I. (b and c) The effect of IGF-I on the growth of Leishmania within macrophages is shown. RAW 264.7 cells were infected with L. major promastigotes (b) or amastigotes (c) treated with or without 50 ng/mL rIGF-I and incubated for 48 h. (one-way ANOVA and Student’s test) compared to the control without rIGF-I.

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