Decreased IL-33 Production Contributes to Trophoblast Cell Dysfunction in Pregnancies with Preeclampsia

Figure 4

Treatment with IL-33 shRNA weakened the proliferation, invasion, and migration of HTR8/SVneo cells. (a, b) IL-33 knockdown significantly decreased the area of the wound in the wound healing assay (40x; scale bar, 50 μm). (c) IL-33 knockdown significantly weakened the proliferation of cells. (d–f) The migration and invasion potency of HTR8/SVneo cells was decreased in the IL-33 knockdown group compared with scrambled shRNA group (200x; scale bar, 200 μm) (t-test, , ).

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