Chronic Inflammation as a Link between Periodontitis and Carcinogenesis

Figure 1

Association of periodontal bacteria with orodigestive cancer. Periodontitis has been associated with orodigestive cancers through the chronic inflammation generated in the oral cavity and the concomitant mobilization of inflammatory mediators to distal sites in the human body, as well as a direct carcinogenic effect mediated by periodontitis-associated bacterial species either directly in oral cells or by migrating from the oral cavity.