Found an IL-17A producing subset of dendritic epidermal T cells that activate after skin injury. Further showed in vitro that exogenous IL-17A induced keratinocytes to produce antimicrobial peptides important for wound healing.
IL-17, subtype not specified, neutralizing antibody treatment decreased M2 macrophage numbers and increased T cell-activating cytokines (IL-2, IL-6, and IL-12) as well as T cell numbers. Type I collagen levels were decreased but no changes were found in the wound area or length.
