Inhibition of MAPK and STAT3-SOCS3 by Sakuranetin Attenuated Chronic Allergic Airway Inflammation in Mice
Sakuranetin did not affect cell viability in vitro and reduced NO, IL-1β, and IL-6 levels in the LPS-stimulated RAW 264.7 cell line. (a) Cell viability with different doses of sakuranetin. (b) NO measurement after LPS stimulation with pretreatment of sakuranetin doses. ,, and #. All doses of SK were different compared to the control group (). (c) IL-1β and IL-6 RNA expression after LPS stimulation with pretreatment of sakuranetin doses; # compared with SAL, compared with SAL, + compared with OVA, and $ compared with OVA and SK 20 μg/mL. Data represent from a pull of cells performed in duplicate.