Inhibition of MAPK and STAT3-SOCS3 by Sakuranetin Attenuated Chronic Allergic Airway Inflammation in Mice

Figure 7

Sakuranetin did not affect cell viability in vitro and reduced NO, IL-1β, and IL-6 levels in the LPS-stimulated RAW 264.7 cell line. (a) Cell viability with different doses of sakuranetin. (b) NO measurement after LPS stimulation with pretreatment of sakuranetin doses. , , and ^#. All doses of SK were different compared to the control group (). (c) IL-1β and IL-6 RNA expression after LPS stimulation with pretreatment of sakuranetin doses; ^# compared with SAL, compared with SAL, ⁺ compared with OVA, and ^$ compared with OVA and SK 20 μg/mL. Data represent from a pull of cells performed in duplicate.

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