Phenolic Compounds Isolated from Calea uniflora Less. Promote Anti-Inflammatory and Antioxidant Effects in Mice Neutrophils (Ex Vivo) and in Mice Pleurisy Model (In Vivo)

Figure 4

Effect of noreugenin or α-hydroxy-butein upon IL-1β (a), IL-17A (b), and IL-10 (c) levels in carrageenan-induced inflammation in the mouse model of pleurisy. Control = animals treated with saline solution (NaCl 0.9%) only. Cg = animals treated with carrageenan (1%) only. Dex = animals pretreated with dexamethasone (0.5 mg/kg, i.p.). NRG = noreugenin (5 mg/kg, i.p.). AH-BU = α-hydroxy-butein (2.5 mg/kg, i.p.). Bars represent the of 5 animals. The values in brackets represent the percentages of inhibition. and compared to the positive control group (Cg); ANOVA/Newman–Keuls test.

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