Phenolic Compounds Isolated from Calea uniflora Less. Promote Anti-Inflammatory and Antioxidant Effects in Mice Neutrophils (Ex Vivo) and in Mice Pleurisy Model (In Vivo)

Table 1

Effects of noreugenin (NRG) or α-hydroxy-butein (AH-BU) on myeloperoxidase activity of the neutrophils obtained from fluid leakage from the mouse peritoneal cavity 4 h after an intraperitoneal injection of oyster glycogen solution.

Groups	Concentrations (μm)	MPO (mU/mL) (% of inhibition)
Control
LPS
Noreugenin	1
	2.5
	5
	10
	50
α-Hydroxy-butein	1
	2.5
	5
	10
	50

MPO: myeloperoxidase; LPS: lipopolysaccharide. Cells were pretreated with different concentrations of noreugenin (NRG: 1–50 μM) or α-hydroxy-butein (AH-BU: 1–50 μM) for 0.5 h and then stimulated with LPS (5 μg/mL) for 18 h. Control = cells treated with sterile phosphate-buffered saline (PBS, pH 7.6) only. LPS = cells treated with LPS (5 μg/mL) only. Each group represents the of experiments conducted in triplicate from three to six animals. compared to the positive control group (LPS); ANOVA/Newman–Keuls test.