Irisin Attenuates Neuroinflammation and Prevents the Memory and Cognitive Deterioration in Streptozotocin-Induced Diabetic Mice

<div>Irisin prevented STZ-induced working memory deterioration in DM mice. (a) STZ treatment caused significantly decreased spontaneous alternation of DM mice in the Y maze test. Irisin could prevent the decrease of the working memory performance of DM mice. (b) Neither STZ nor irisin could change the total arm entries of these mice. 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Mediators of Inflammation

fig1

Figure 1

Figure 1: Irisin Attenuates Neuroinflammation and Prevents the Memory and Cognitive Deterioration in Streptozotocin-Induced Diabetic Mice 