Irisin Attenuates Neuroinflammation and Prevents the Memory and Cognitive Deterioration in Streptozotocin-Induced Diabetic Mice

Figure 5

Irisin reduced the level of IL-6 and IL-1β in the CSF of DM mice exposed to STZ. (a) STZ increased the level of IL-1β in the CSF of DM mice, but irisin treatment could reduce the upregulation of IL-1β. (b) STZ increased the level of IL-6 in the CSF of DM mice, and irisin treatment could reduce the upregulation of IL-6. All data are expressed as . . vs. Cont; vs. STZ.

(a)

(b)