Mediators of Inflammation / 2019 / Article / Fig 1

Research Article

Infection with Opportunistic Bacteria Triggers Severe Pulmonary Inflammation in Lupus-Prone Mice

Figure 1

Lupus-prone mice exhibited delayed bacterial clearance and severer lung injury after infection. (a) B6 and B6/lpr mice were infected with H. influenzae (strain 86-028NP) intranasally. Their bodyweight changes were monitored until fully recovered. B6 mice: circle; B6/lpr mice: square. Mice were infected as described before and sacrificed on Days 2 (D2) and 10 (D10) after infection. (b) Bacteria in the BALF and lungs were recovered and determined. Lung pathology was examined by H&E staining. (c) H&E staining of representative animals. Original magnification: 40x; inlets: 200x. (d) Histopathological mean inflammation scores of lungs. Data were expressed as . mice for each treatment group. , , and . ns: no significant difference; U.D.: under the limit of detection. This experiment is representative of three individual experiments.

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