Chemokine and Cytokine Cascade Caused by Skewing of the Th1-Th2 Balance Is Associated with High Intracranial Pressure in HIV-Associated Cryptococcal Meningitis

Figure 3

Principal component analysis scores and weightings in a heat map. (a) Variance of the 4 principal component scores among the 65 HIV-infected patients. PC1 and PC3 were correlated with HIV-associated cryptococcal meningitis (HCM). PC1 was composed primarily of proinflammatory cytokines such as CD40L, IL-1β, IL-8, IL-12, and TNF-α and anti-inflammatory cytokines such as IFN-α2, TNF-β, and IL-8. PC3 was majorly driven by MCP-1, IL-6, and IL-Rα. (b) Proportion of variance in the 4 principal components in the 39 HCM patients. PC1 was correlated with high intracranial pressure (HICP). Component loading indicated that CD40L, IL-12, IL-1β, IFN-α2, TNF-α, TNF-β, IL-4, and IL-10 were the main components of PC1.

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