Macrophage Migration Inhibitory Factor Promotes the Interaction between the Tumor, Macrophages, and T Cells to Regulate the Progression of Chemically Induced Colitis-Associated Colorectal Cancer

<div>MIF deficiency facilitates increased tumor development. After 68 days post induction (d.p.i). (a) Colons from (I) healthy WT, (II) WT CRC, (III) healthy MIF<sup>-/-</sup>, and (IV) MIF<sup>-/-</sup> CRC mice were obtained and (b) measured from caecum to anus. Then, (c) the colons were opened longitudinally to measure (d) tumor number and (e) diameter to determine (f) tumor burden. 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602Z"></path></g><g transform="matrix(.013,0,0,-0.013,61.53,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>.</span> MIF: macrophage migration inhibitory factor; CRC: colorectal cancer; AOM: azoxymethane; DSS: dextran sodium sulfate; d.p.i: days post induction.</div>

Mediators of Inflammation

fig2

Figure 2

Figure 2: Macrophage Migration Inhibitory Factor Promotes the Interaction between the Tumor, Macrophages, and T Cells to Regulate the Progression of Chemically Induced Colitis-Associated Colorectal Cancer 

Figure 2 | Macrophage Migration Inhibitory Factor Promotes the Interaction between the Tumor, Macrophages, and T Cells to Regulate the Progression of Chemically Induced Colitis-Associated Colorectal Cancer 