Macrophage Migration Inhibitory Factor Promotes the Interaction between the Tumor, Macrophages, and T Cells to Regulate the Progression of Chemically Induced Colitis-Associated Colorectal Cancer

Figure 5

The macrophage population in the tumor stroma is diminished in the absence of MIF. (a) F4/80⁺ CD11b+ macrophage percentage and (b) representative histograms of macrophage staining in the lamina propria from the colon of a mouse with colorectal cancer. (c) Immunohistochemical analysis of macrophages (F4/80⁺ cells) and (d) quantification of the number of macrophages in the tumor margin (M) and tumor stroma (S). Data are representative of three independent experiments and are plotted as the means (±SEM), mice per group; , , and .

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