Review Article
Systematic Review with Meta-Analysis: Fecal Calprotectin as a Surrogate Marker for Predicting Relapse in Adults with Ulcerative Colitis
Table 2
Assessment of diagnostic accuracy and heterogeneity in subgroup analysis.
| Category | Number of studies | Sensitivity | Specificity | PLR | NLR | DOR | (%) of DOR |
| Total | 14 | 0.75 (0.70–0.79) | 0.77 (0.74–0.80) | 3.45 (2.31–5.14) | 0.37 (0.28–0.49) | 10.54 (6.16–18.02) | 57.0 | Number of patients | | | | | | | | ≥80 | 6 | 0.78 (0.72-0.83) | 0.75 (0.71-0.79) | 3.39 (1.77-6.51) | 0.32 (0.23-0.43) | 11.18 (4.96-25.19) | 72.5 | <80 | 8 | 0.68 (0.59-0.76) | 0.81 (0.76-0.85) | 3.38 (2.10-5.43) | 0.44 (0.30-0.63) | 9.60 (4.57-20.15) | 39.5 | Mean age | | | | | | | | ≥40 | 10 | 0.73 (0.67-0.79) | 0.75 (0.71-0.79) | 3.34 (2.00-5.58) | 0.40 (0.30-0.53) | 9.61 (4.75-19.47) | 62.3 | <40 | 4 | 0.77 (0.68-0.85) | 0.81 (0.76-0.86) | 3.92 (2.96-5.20) | 0.30 (0.15-0.62) | 13.44 (6.31-28.60) | 34.9 | Male ratio | | | | | | | | ≥50% | 10 | 0.75 (0.70-0.80) | 0.75 (0.72-0.79) | 3.71 (1.97-5.10) | 0.37 (0.26-0.52) | 9.98 (5.16-19.32) | 67.7 | <50% | 4 | 0.70 (0.53-0.84) | 0.84 (0.78-0.89) | 4.31 (2.38-7.80) | 0.39 (0.24-0.62) | 12.49 (5.31-29.37) | 0 | FC assay | | | | | | | | Bühlmann | 4 | 0.75 (0.65-0.83) | 0.87 (0.80-0.91) | 5.07 (3.32-7.75) | 0.34 (0.16-0.72) | 15.35 (5.28-44.61) | 44.8 | Not Bühlmann | 10 | 0.74 (0.68-0.80) | 0.75 (0.71-0.78) | 3.05 (1.98-4.69) | 0.38 (0.28-0.52) | 9.34 (5.06-17.24) | 58.0 | Cutoff value | | | | | | | | ≥150 μg/g | 9 | 0.71 (0.65-0.78) | 0.86 (0.82-0.89) | 4.42 (3.00-6.53) | 0.38 (0.26-0.55) | 14.06 (7.17-27.58) | 49.9 | <150 μg/g | 5 | 0.79 (0.71-0.85) | 0.64 (0.58-0.69) | 2.19 (1.32-3.64) | 0.36 (0.25-0.50) | 6.72 (2.95-15.47) | 59.8 | Follow-up time | | | | | | | | ≥1 y | 12 | 0.73 (0.68-0.78) | 0.81 (0.78-0.84) | 3.66 (2.52-5.31) | 0.38 (0.28-0.50) | 11.18 (6.32-19.78) | 59.8 | <1 y | 2 | 0.89 (0.72-0.98) | 0.44 (0.33-0.57) | 2.20 (0.66-7.28) | 0.31 (0.11-0.88) | 7.01 (0.92-53.25) | 41.0 |
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