Cytokines and Chemokines in Pediatric Appendicitis: A Multiplex Analysis of Inflammatory Protein Mediators
Table 2
Inflammatory protein mediators and their test characteristics in children with suspected appendicitis. Area under receiver operator characteristic curve and other test characteristics calculations are based on classification of patients with nonappendicitis abdominal pain and appendicitis (nonappendicitis sepsis group is excluded).
Nonappendicitis abdominal pain ()
Appendicitis ()
Nonappendicitis sepsis ()
AUROC
Cut-off (%correct)
Sensitivity: specificity
LR+ : LR-
CRP, mean (SD)1
7.6 (14.1)
46.6 (51.8)
70.5 (44.3)
0.8472
7.9 (78.1)
80.5 : 75.6
3.31 : 0.26
IL-6, mean (SD)2
28.0 (44.3)
1113.8 (6165.1)
4834.8 (20025.2)
0.8101
68.9 (69.4)
48.1 : 90.1
4.87 : 0.58
IL-8, mean (SD)2
24.4 (20.0)
164.5 (914.5)
385.8 (922.5)
0.5425
33.2 (59.4)
34.2 : 83.5
2.08 : 0.79
IL-10, mean (SD)2
19.9 (23.7)
94.9 (297.0)
271.4 (864.9)
0.6294
30.1 (62.26)
35.1 : 87.8
2.87 : 0.74
MCP-1, mean (SD 2)
88.3 (102.7)
361.5 (1129.2)
605.0 (1786.3)
0.6813
133.8 (68.4)
45.5 : 90.1
4.60 : 0.61
PCT, mean (SD)3
6.1 (2.3)
10.0 (9.2)
33.1 (52.0)
0.7382
6.5 (69.2)
57.7 : 80.8
3.00 : 0.52
SAA, mean (SD)1
122.7 (254.5)
248.3 (377.0)
92.5 (83.5)
0.7514
73.2 (73.6)
93.6 : 53.1
2.05 : 0.12
CRP: c-reactive protein; IL: interleukin; MCP: monocyte chemoattractant protein; PCT: procalcitonin; SAA: serum amyloid A; AUROC: area under receiver operating characteristic; LR: likelihood ratio. 1Concentrations measured in mg/L, 2concentrations measured in pg/mL, 3concentrations measured in ng/mL.
