Interleukin-37: The Effect of Anti-Inflammatory Response in Human Coronary Artery Endothelial Cells

<div>IL-37 is a “dual function” anti-inflammation cytokine. IL-37 exerts a biological role extracellularly. The IL-37 precursor is exported from the cell into the extracellular space to take a series of biological effects. IL-18 binds to IL-18R<i>α</i> at the cell surface and recruits the IL-18R<i>β</i> chain to form a functional complex. IL-37 is combined with IL-18R<i>α</i> side chain to prevent the formation of IL-18 functional complex.</div>

Mediators of Inflammation

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Figure 2

Figure 2: Interleukin-37: The Effect of Anti-Inflammatory Response in Human Coronary Artery Endothelial Cells 