Interleukin-37: The Effect of Anti-Inflammatory Response in Human Coronary Artery Endothelial Cells

Figure 3

IL-37 signaling pathway induced by TLR2/4 extracellularly and intracellularly. The translocation of the activated NF-κB induced by TLR2/4 into the nucleus for binding to NF-κB-specific DNA-binding sites, resulting in the regulation of the transcription of target genes, such as ICAM-1. On one hand, IL-37 can inhibit the TLR2/4-NF-κB signaling pathway by suppressing the phosphorylation of NF-κB or binding to Smad3 to inhibit transcription in the nucleus. On the other hand, IL-37 can combine with IL-18Rα side chain to prevent the formation of IL-18 functional complex to suppress the production of proinflammatory cytokine extracellularly.