Interleukin-12p35 Deficiency Reverses the Th1/Th2 Imbalance, Aggravates the Th17/Treg Imbalance, and Ameliorates Atherosclerosis in ApoE-/- Mice
Effect of IL-12p35 deficiency on the stability of atherosclerotic plaque in the aortic sections of ApoE-/- mice. The aortic roots of (a) α-SMA-positive area (20x), (b) collagen-positive area (20x), (c) CD4+ T lymphocyte (40x), and (d) macrophages (40x) were measured in the two groups. ApoE KO = ApoE-/-; DKO = ApoE-/- IL-12p35-/-; for each group. .